Weekly Digests

2026

June

AACR IO 2026

June 3, 2026

The ACIR team attended the AACR IO meeting held on February 18-21, 2026 in Los Angeles, CA, USA. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. T cellsPhilip D. GreenbergRafi AhmedFred RamsdellAlexander MarsonRobert G. NewmanOwen N. Witte Checkpoint blockadeFathia Mami-ChouaiDario A. VignaliMegan...

Agonist anti-CD40 converts Tregs from foes to friends

June 2, 2026

Recent investigations into the use of agonist anti-CD40 for cancer immunotherapy have shown that this treatment not only enhances APC functions, but also reduces regulatory T cells (Tregs) within the tumor microenvironment (TME), despite a lack of CD40 on these cells. Exploring the mechanism by which this occurs, and whether it might contribute...

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